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Desloratadine (Clarinex), the major active metabolite of loratadine (Claritin), is a nonsedating antihistamine used for the treatment of seasonal allergies and hives. Previously we reported that the formation of 3-hydroxydesloratadine, the major human metabolite of desloratadine, involves three sequential reactions, namely N-glucuronidation by UGT2B10 followed by 3-hydroxylation by CYP2C8 follo...
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Measurement of cel l -mediated cytotoxic i ty (CMC) 1 directed to cell surface antigens has been faci l i ta ted by the e laborat ion of a re la t ively simple reproducible test in which ~lCr is released from labeled target cells (1-5). Other invest igators have examined certain facets of the test (6-18) and have appl ied the technique to studies of tumor allograft systems (3-5, 16, 19, 20) and...
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ژورنال
عنوان ژورنال: Synthesis
سال: 2002
ISSN: 0039-7881,1437-210X
DOI: 10.1055/s-2002-34473